Mara Ferrandi Selected Research

Istaroxime

1/2022	SERCA2a stimulation by istaroxime improves intracellular Ca2+ handling and diastolic dysfunction in a model of diabetic cardiomyopathy.
8/2013	Istaroxime stimulates SERCA2a and accelerates calcium cycling in heart failure by relieving phospholamban inhibition.
8/2011	Combining SERCA2a activation and Na-K ATPase inhibition: a promising new approach to managing acute heart failure syndromes with low cardiac output.
1/2007	Istaroxime, a stimulator of sarcoplasmic reticulum calcium adenosine triphosphatase isoform 2a activity, as a novel therapeutic approach to heart failure.

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Mara Ferrandi Research Topics

Disease

12	Hypertension (High Blood Pressure) 03/2016 - 12/2002
7	Essential Hypertension 01/2021 - 11/2004
5	Hypertrophy 01/2014 - 08/2004
4	Heart Failure 01/2022 - 01/2007
3	Proteinuria 11/2014 - 02/2010
2	Cardiomegaly (Heart Hypertrophy) 01/2014 - 08/2004
1	Diabetic Cardiomyopathies 01/2022
1	Fibrosis (Cirrhosis) 01/2022
1	Cardiotoxicity 01/2021
1	Cardiac Arrhythmias (Arrythmia) 01/2021
1	Neoplasms (Cancer) 01/2021
1	Ischemia 10/2016
1	Kidney Diseases (Kidney Disease) 10/2016
1	Reperfusion Injury 10/2016
1	Albuminuria 12/2014
1	Disease Progression 11/2014
1	Acute Kidney Injury (Acute Renal Failure) 03/2013
1	Low Cardiac Output 08/2011
1	IGA Glomerulonephritis (IGA Nephropathy) 02/2010
1	Renal Insufficiency (Renal Failure) 01/2009
1	Stroke (Strokes) 05/2007
1	Myocardial Infarction 05/2007
1	Cardiomyopathies (Cardiomyopathy) 03/2006
1	Hyperglycemia 12/2002

Drug/Important Bio-Agent (IBA)

11	adducinIBA 11/2014 - 12/2002
10	Ouabain (G Strophanthin)IBA 10/2016 - 08/2004
7	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2006
6	rostafuroxinIBA 01/2021 - 12/2002
5	Antihypertensive Agents (Antihypertensives)IBA 01/2021 - 12/2002
4	IstaroximeIBA 01/2022 - 01/2007
4	SaltsIBA 12/2014 - 05/2007
4	Adenosine Triphosphatases (ATPase)IBA 11/2014 - 03/2006
3	Pharmaceutical PreparationsIBA 01/2022 - 11/2010
3	CalciumIBA 08/2013 - 01/2007
3	SodiumIBA 01/2009 - 09/2005
2	nephrinIBA 12/2014 - 11/2014
2	DiureticsIBA 05/2007 - 12/2002
1	Sarcoplasmic Reticulum Calcium-Transporting ATPasesIBA 01/2022
1	human ERBB2 proteinIBA 01/2021
1	Trastuzumab (Herceptin)FDA Link 01/2021
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2021
1	AnthracyclinesIBA 01/2021
1	Losartan (Cozaar)FDA LinkGeneric 01/2021
1	Hormones (Hormone)IBA 10/2016
1	UromodulinIBA 12/2014
1	Therapeutic UsesIBA 11/2014
1	Phosphotransferases (Kinase)IBA 01/2014
1	Messenger RNA (mRNA)IBA 01/2014
1	phospholambanIBA 08/2013
1	Biomarkers (Surrogate Marker)IBA 03/2013
1	Furosemide (Lasix)FDA LinkGeneric 08/2011
1	Member 1 Solute Carrier Family 12IBA 08/2011
1	nasIBA 03/2011
1	Biological ProductsIBA 11/2010
1	Sodium-Potassium-Exchanging ATPase (Sodium, Potassium ATPase)IBA 01/2009
1	Protein Isoforms (Isoforms)IBA 01/2007
1	Calcium-Transporting ATPases (Ca2+ ATPase)IBA 01/2007
1	Cardiac GlycosidesIBA 03/2006
1	DigitoxigeninIBA 09/2005
1	Hydrochlorothiazide (Esidrix)FDA LinkGeneric 12/2002
1	ReninIBA 12/2002
1	AldosteroneIBA 12/2002

Therapy/Procedure

8	Therapeutics 01/2021 - 03/2006
1	Nephrectomy 10/2016
1	Precision Medicine 03/2016